Table 4.
Increased proteins in macrophages infected with Paracoccidioides brasiliensis yeast cells involved in stress response.
| Accession number1 | Protein description and biological process2 | Score3 | Fold change4 |
|---|---|---|---|
| Stress response | |||
| P07203 | Glutathione peroxidase 1 | 4743.71 | 2.225 |
| Q9Y2Q3 | Glutathione S-transferase kappa 1 | 843.45 | * |
| P09211 | Glutathione S-transferase P | 22608.57 | 1.682 |
| K7EN27 | Maillard deglycase (Fragment) | 13395.05 | 2.117 |
| K7ELW0 | Parkinson disease protein 7 | 17649.65 | 3.706 |
| P32119 | Peroxiredoxin-2 | 1915.38 | 1.896 |
1 Accession number of matched protein from Homo sapiens’ macrophages Uniprot database (https://www.uniprot.org/).
2 Proteins annotation from Homo sapiens’ database or by homology in NCBI database (http://www.ncbi.nlm.nih.gov/) and biological process according to the classification of KEGG (https://www.genome.jp/kegg/), UniProt database (https://www.uniprot.org/), NCBI database (http://www.ncbi.nlm.nih.gov/) and CORUM database (http://mips.helmholtz-muenchen.de/corum/).
3 PLGS score is the result of different mathematical models for peptide and fragment assign prediction.
4 Fold-change values were obtained by dividing the values of protein abundance (in fmol) from macrophages during infection by live PB by the abundance in the uninfected macrophages. Proteins with a minimum fold-change of 50% (≥ 1.5) were considered to be upregulated.
* Proteins detected only in infected macrophages.
A fold equal to or higher than 1.5 was considered.