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. 2023 Nov 16;13:1275954. doi: 10.3389/fcimb.2023.1275954

Table 5.

Some proteins decreased in macrophages infected vwith Paracoccidioides brasiliensis yeast cells involved in immune response.

Accession number1 Protein description and biological process2 Score3 Fold change4
Immune response
O15143 Actin-related protein 2/3 complex subunit 1B 8740.81 0.631
O15144 Actin-related protein 2/3 complex subunit 2 3617.00 *
O15145 Actin-related protein 2/3 complex subunit 3 17431.37 *
R4GN08 Actin-related protein 2/3 complex subunit 4 (Fragment) 1106.88 *
O15511 Actin-related protein 2/3 complex subunit 5 3627.45 *
F8WE84 Actin-related protein 3 9712.19 *
D6RBL5 Annexin 13850.32 0.650
P04083 Annexin A1 18072.62 *
P08758 Annexin A5 30602.12 0.644
O43150 Arf-GAP with SH3 domain_ ANK repeat and PH domain-containing protein 2 594.14 *
G5E9J0 Arp2/3 complex 34 kDa subunit 475.38 *
P61769 Beta-2-microglobulin 3926.66 *
A0A7I2V440 Cathepsin B 6042.11 *
P25774 Cathepsin S 1155.57 *
P36222 Chitinase-3-like protein 1 1597.86 *
Q07021 Complement component 1 Q subcomponent-binding protein_ mitochondrial 7230.48 *
A0A7P0TB36 Endoplasmic reticulum chaperone BiP 21012.03 0.582
P54652 Heat shock-related 70 kDa protein 2 11903.81 0.001
P09429 High mobility group protein B1 1668.83 *
C9J0D1 Histone H2A 7828.83 *
P0C0S8 Histone H2A type 1 8902.71 *
Q96QV6 Histone H2A type 1-A 3271.32 *
P04908 Histone H2A type 1-B/E 8902.71 *
Q93077 Histone H2A type 1-C 8902.71 *
P20671 Histone H2A type 1-D 8902.71 *
Q96KK5 Histone H2A type 1-H 8902.71 *
Q99878 Histone H2A type 1-J 8902.71 *
Q6FI13 Histone H2A type 2-A 8902.71 *
Q8IUE6 Histone H2A type 2-B 2747.75 *
Q16777 Histone H2A type 2-C 8902.71 *
Q9BTM1 Histone H2A.J 8902.71 *
Q71UI9 Histone H2A.V 8676.91 *
P0C0S5 Histone H2A.Z 8676.91 *
P16104 Histone H2AX 3273.08 *
U3KQK0 Histone H2B 16807.41 *
Q96A08 Histone H2B type 1-A 7130.46 *
P33778 Histone H2B type 1-B 17593.68 *
P62807 Histone H2B type 1-C/E/F/G/I 16807.41 *
P58876 Histone H2B type 1-D 16807.41 *
Q93079 Histone H2B type 1-H 16807.41 *
P06899 Histone H2B type 1-J 17593.68 *
O60814 Histone H2B type 1-K 16807.41 *
Q99880 Histone H2B type 1-L 16807.41 *
Q99879 Histone H2B type 1-M 16807.41 *
Q99877 Histone H2B type 1-N 16807.41 *
P23527 Histone H2B type 1-O 17593.68 *
Q16778 Histone H2B type 2-E 17593.68 *
A0A2R8Y619 Histone H2B type 2-E1 311.58 *
Q5QNW6 Histone H2B type 2-F 16807.41 *
Q8N257 Histone H2B type 3-B 17593.68 *
P57053 Histone H2B type F-S 16800.03 *
Q6NXT2 Histone H3.3C 3853.37 *
P62805 Histone H4 7844.59 *
P05107 Integrin beta-2 2518.87 *
P33241 Lymphocyte-specific protein 1 820.58 *
P14174 Macrophage migration inhibitory factor 4042.46 *
Q96E17 Ras-related protein Rab-3C 1115.57 *
P19793 Retinoic acid receptor RXR-alpha 654.98 *
P28702 Retinoic acid receptor RXR-beta 1177.33 *
P48443 Retinoic acid receptor RXR-gamma 630.23 *
H0Y858 Toll-like receptor 9 (Fragment) 624.89 *
A0A499FJK2 Transforming growth factor beta 618.77 *

1 Accession number of matched protein from Homo sapiens’ macrophages Uniprot database (https://www.uniprot.org/).

2 Proteins annotation from Homo sapiens’ database or by homology in NCBI database (http://www.ncbi.nlm.nih.gov/) and biological process according to the classification of KEGG (https://www.genome.jp/kegg/), UniProt database (https://www.uniprot.org/), NCBI database (http://www.ncbi.nlm.nih.gov/) and CORUM database (http://mips.helmholtz-muenchen.de/corum/).

3 PLGS score is the result of different mathematical models for peptide and fragment assign prediction.

4 Fold-change values were obtained by dividing the values of protein abundance (in fmol) from macrophages during infection by live PB by the abundance in the uninfected macrophages. Proteins with a minimum fold-change of 50% (≤ 0.67) were considered to be dowregulated.

* Proteins detected only in uninfected macrophages.

A fold equal to or less than 0.67 was considered.