Table 3.
Multivariate analysis (Cox Regression) for OS.
| Characteristics | Univariate cHR (95% CI) |
p | Multivariate aHR (95% CI) | p |
|---|---|---|---|---|
| Biologic Factors | ||||
| Sex (Female vs Male) | 0.97 (0.79-1.19) | 0.782 | ||
| Age (≤ 65y vs >65) | 1.05 (0.84-1.31) | 0.675 | ||
| Sarcomatoid features | 2.01(1.46-2.75) | <0.001 | 1.7 (1.19-2.42) | 0.004 |
| Sites of metastases (1 vs >1) | 0.72 (0.58-0.88) | 0.001 | 0.88 (0.67-1.17) | 0.395 |
| De novo vs recurrent disease | 2.31 (1.86-2.88) | <0.001 | 0.96 (0.71-1.23) | 0.769 |
| Favorable IMDC risk | 0.30 (0.21-0.42) | <0.001 | 0.51 (0.34-0.77) | 0.001 |
| Brain Metastases | 1.53 (1.17-1.99) | 0.002 | 2.2 (1.58-3.1) | <0.001 |
| Bone Metastases | 1.50 (1.22-1.84) | <0.001 | 1.46 (1.13-1.89) | 0.004 |
| Socioeconomic Factors | ||||
| No insurance | 2.95 (2.39-3.65) | <0.001 | 2.1 (1.52-2.88) | <0.001 |
| Foreigners | 1.31 (1.05-1.63) | 0.018 | 0.95 (0.7-1.28) | 0.735 |
| Therapeutic Factors | ||||
| Nephrectomy | 0.36 (0.29-0.44) | <0.001 | 0.58 (0.42-0.79) | 0.001 |
| Metastasectomy | 0.23 (0.14-0.36) | <0.001 | 0.2 (0.11-0.36) | <0.001 |
| 0 vs ≥ 1 lines of treatment | 2.97 (2.43-3.64) | <0.001 | 2.02 (1.43-2.85) | <0.001 |
Bold values are those that reached statistical significance.