Table 3.

Standardized incidence ratio of bladder cancer and rectum cancer after prostate cancer diagnosis among patients receiving radiotherapy or without radiotherapy.

	Bladder cancer		Rectum cancer
	Adjusted SIR (95% CI)	P-value	Adjusted SIR (95% CI)	P-value
RT vs US general population
All patients	1.44(1.38- 1.50)	<0.05	1.48(1.35- 1.62)	<0.05
Year of diagnosis
1995-1999	1.37(1.18-1.57)	<0.05	1.21(0.90-1.58)	NS
2000-2004	1.44(1.29-1.60)	<0.05	1.32(1.05-1.65)	<0.05
2005-2009	1.34(1.21-1.48)	<0.05	1.58(1.28-1.93)	<0.05
2010-2015	1.54(1.41-1.68)	<0.05	1.49(1.19-1.85)	<0.05
Age at diagnosis
<60 years	NA	NA	NA	NA
60-64 years	2.08(1.44-2.91)	<0.05	1.20(0.55-2.27)	NS
65-69 years	1.72(1.41-2.07)	<0.05	1.45(0.98-2.06)	NS
70-74 years	1.33(1.16- 1.52)	<0.05	1.35(1.03-1.73)	<0.05
75-79 years	1.36(1.24-1.49)	<0.05	1.44(1.18-1.74)	<0.05
80-84 years	1.38(1.27-1.50)	<0.05	1.47(1.22-1.75)	<0.05
85+ years	1.53(1.42-1.65)	<0.05	1.66(1.38-1.98)	<0.05
Survival months
5-10 years	1.27(1.19-1.35)	<0.05	1.18(1.02-1.35)	<0.05
>10 years	1.61(1.52-1.70)	<0.05	1.87(1.64-2.11)	<0.05
Undergoing surgery vs US general population
All patients	1.00(0.98-1.02)	NS	0.92(0.89-0.95)	<0.05
Year of diagnosis
1995-1999	0.92(0.86- 0.97)	<0.05	0.93(0.84- 1.02)	NS
2000-2004	0.98(0.93-1.03)	NS	0.92(0.84-1.01)	NS
2005-2009	1.03(0.99- 1.08)	NS	0.90(0.83- 0.98)	NS
2010-2015	1.00(0.96- 1.04)	NS	0.97(0.89- 1.05)	NS
Age at diagnosis
<60 years	NA	NA	NA	NA
60-64 years	1.32(1.22- 1.42)	<0.05	0.98(0.87- 1.11)	NS
65-69 years	1.07(1.01-1.14)	<0.05	0.85(0.77- 0.94)	<0.05
70-74 years	0.97(0.93-1.02)	NS	0.88(0.81-0.96)	<0.05
75-79 years	0.96(0.92-1.01)	NS	0.90(0.83-0.98)	<0.05
80-84 years	0.95(0.91- 0.99)	<0.05	0.85(0.78-0.92)	<0.05
85+ years	0.94(0.91- 0.98)	<0.05	0.94(0.87-1.01)	NS
Survival months
5-10 years	1.00(0.98-1.02)	NS	0.97(0.92-1.02)	NS
>10 years	0.96(0.94- 0.99)	<0.05	0.88(0.84- 0.93)	<0.05

SIR, standardized incidence ratio; RT, radiotherapy; NA, not applicable; NS: no significance.