. 2023 Nov 16;14:1259350. doi: 10.3389/fendo.2023.1259350

Table 5.

Receiver operating characteristic curve for diagnosis vs. low muscle mass.

Men									Women
	AUC		95% CI		Cut off	Specificity	Sensitivity	vs. grip		AUC		95% CI		Cut off	Specificity	Sensitivity	vs. grip
	AUC		Min	Max	Cut off	Specificity	Sensitivity	vs. grip		AUC		Min	Max	Cut off	Specificity	Sensitivity	vs. grip
Quantity									Quantity
CSA, cm²	0.867	*	0.820	0.914	55.2	0.785	0.824	<0.001	CSA, cm²	0.791		0.720	0.861	38.8	0.729	0.744	0.139
CSA / height, cm	0.878	*	0.833	0.923	0.328	0.801	0.824	<0.001	CSA / height, cm	0.807		0.734	0.880	0.245	0.814	0.692	0.089
CSA / height², %	0.876	*	0.831	0.921	0.201	0.753	0.853	<0.001	CSA / height², %	0.805		0.727	0.883	0.16	0.802	0.692	0.120
CSA / weight, cm²/kg	0.633		0.561	0.705	0.905	0.554	0.691	0.304	CSA / weight, cm²/kg	0.499		0.402	0.595	0.783	0.458	0.641	0.003
CSA / BMI, 10⁴·cm⁴/kg	0.645		0.570	0.720	2.43	0.667	0.603	0.356	CSA / BMI, 10⁴·cm⁴/kg	0.506		0.408	0.603	1.94	0.559	0.564	0.007
ASM, kg	0.904	*	0.868	0.941	19.9	0.790	0.882	<0.001	ASM, kg	0.922	*	0.885	0.960	13.0	0.836	0.846	<0.001
SMI, kg / m²	–		–	–	–	–	–	–	SMI, kg / m²	–		–	–	–	–	–	–
ASM / weight, %	0.642		0.565	0.719	31.8	0.699	0.603	0.402	ASM / weight, %	0.587		0.482	0.692	27.0	0.571	0.641	0.014
ASM / BMI, m²	0.605		0.524	0.686	0.871	0.656	0.544	0.047	ASM / BMI, m²	0.572		0.469	0.674	0.638	0.559	0.590	0.004
Quality									Quality
CTV, HU	0.509		0.428	0.589	54.9	0.516	0.529	0.008	CTV, HU	0.465		0.362	0.569	50.9	0.542	0.487	<0.001
CTV / BMI, HU·m²/kg	0.784		0.721	0.847	2.40	0.667	0.824	0.051	CTV / BMI, HU·m²/kg	0.787		0.709	0.865	2.43	0.695	0.769	0.315
KES / CSA, N/cm²	0.534		0.452	0.615	7.99	0.608	0.485	0.021	KES / CSA, N/cm²	0.526		0.426	0.626	6.98	0.508	0.538	<0.001
Quality× Quantity									Quality× Quantity
CSA × CTV, cm²·HU	0.814	*	0.759	0.870	3070	0.720	0.779	<0.001	CSA × CTV, cm²·HU	0.737		0.662	0.813	2072	0.605	0.821	0.664
CSA × CTV / height, cm·HU	0.829	*	0.777	0.880	17.9	0.747	0.765	<0.001	CSA × CTV / height, cm·HU	0.748		0.669	0.826	13.0	0.678	0.744	0.541
CSA × CTV / height², HU	0.829	*	0.778	0.880	0.107	0.742	0.794	<0.001	CSA × CTV / height², HU	0.748		0.666	0.831	0.084	0.689	0.718	0.563
CSA × CTV / weight, cm²·HU/kg	0.609		0.536	0.682	50.3	0.548	0.691	0.101	CSA × CTV / weight, cm²·HU/kg	0.503		0.406	0.600	41.4	0.497	0.590	<0.001
CSA × CTV / BMI, 10⁴·cm⁴·HU/kg	0.614		0.537	0.691	126.0	0.742	0.485	0.089	CSA × CTV / BMI, 10⁴·cm⁴·HU/kg	0.506		0.410	0.602	99.2	0.475	0.590	<0.001
Physical performance									Physical performance
Grip, kg	0.681		0.609	0.753	37.0	0.613	0.632		Grip, kg	0.717		0.632	0.802	22.5	0.650	0.667
KES, N	0.736		0.670	0.802	441	0.613	0.735	0.095	KES, N	0.709		0.629	0.788	275	0.621	0.744	0.860
Leg Power, W	0.668		0.596	0.740	563	0.497	0.750	0.864	Leg Power, W	0.701		0.612	0.790	290	0.687	0.703	0.637
Sit up, times	0.605		0.524	0.685	12.0	0.639	0.530	0.086	Sit up, times	0.465		0.361	0.569	10.0	0.527	0.543	0.002
Walking, m/seconds	0.563		0.481	0.645	1.38	0.565	0.529	0.008	Walking, m/seconds	0.519		0.415	0.623	1.38	0.480	0.513	0.007
Fast walking, m/seconds	0.617		0.542	0.693	1.93	0.516	0.721	0.149	Fast walking, m/seconds	0.499		0.394	0.603	1.78	0.494	0.590	<0.001
Balance, seconds	0.606		0.526	0.686	8.00	0.532	0.662	0.097	Balance, seconds	0.509		0.404	0.614	6.00	0.446	0.615	0.010
Reaction, seconds	0.571		0.492	0.650	0.44	0.659	0.500	0.024	Reaction, seconds	0.519		0.430	0.608	0.47	0.424	0.667	0.003
Age, years	0.632		0.553	0.712	65.0	0.683	0.544	0.211	Age, years	0.496		0.393	0.599	61.0	0.497	0.538	<0.001

Bold is 0.700 or higher, Red bold is 0.900 or higher.

* Significant higher AUC relative to grip (p<0.05).

Abbreviations: AUC, area under the curve; CI, confidence interval; CSA, cross-sectional area; BMI, body mass index; ASM, appendicular skeletal muscle mass; SMI, skeletal muscle mass index; CTV, computed tomography attenuation value; HU, Hounsfield unit; KES, knee extension strength.