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. 2023 Nov 16;14:1259350. doi: 10.3389/fendo.2023.1259350

Table 6.

Receiver operating characteristic curve for diagnosis vs. low muscle function.

Men Women
AUC   95% CI Cut off Specificity Sensitivity vs. SMI AUC   95% CI Cut off Specificity Sensitivity vs. SMI
Min Max Min Max
Quantity Quantity
CSA, cm2 0.853 * 0.779 0.927 51.1 0.838 0.760 0.047 CSA, cm2 0.769 * 0.682 0.856 39.1 0.692 0.742 0.039
CSA / height, cm 0.817 0.738 0.895 0.327 0.694 0.800 0.273 CSA / height, cm 0.727 0.636 0.818 0.258 0.659 0.710 0.145
CSA / height2, % 0.752 0.659 0.844 0.203 0.607 0.760 0.590 CSA / height2, % 0.663 0.567 0.759 0.167 0.665 0.645 0.708
CSA / weight, cm2/kg 0.713 0.603 0.824 0.853 0.721 0.600 0.417 CSA / weight, cm2/kg 0.647 0.542 0.752 0.765 0.665 0.613 0.960
CSA / BMI, 104·cm4/kg 0.848 0.768 0.927 2.29 0.803 0.760 0.200 CSA / BMI, 104·cm4/kg 0.730 0.633 0.828 1.62 0.859 0.548 0.244
ASM, kg 0.867 * 0.793 0.942 19.2 0.769 0.880 0.006 ASM, kg 0.768 * 0.694 0.841 14.0 0.600 0.871 <0.001
SMI, kg / m2 0.774 0.690 0.858 7.18 0.699 0.800 – SMI, kg / m2 0.643 0.539 0.747 5.86 0.600 0.645 –
ASM / weight, % 0.791 0.708 0.875 31.8 0.672 0.840 0.788 ASM / weight, % 0.671 0.559 0.784 26.8 0.622 0.710 0.636
ASM / BMI, m2 0.883 * 0.821 0.946 0.814 0.847 0.800 0.035 ASM / BMI, m2 0.740 0.639 0.842 0.622 0.692 0.677 0.149
Quality Quality
CTV, HU 0.759 0.657 0.861 53.4 0.677 0.840 0.830 CTV, HU 0.720 0.625 0.814 50.9 0.605 0.806 0.320
CTV / BMI, HU·m2/kg 0.559 0.434 0.685 2.20 0.686 0.440 0.026 CTV / BMI, HU·m2/kg 0.584 0.478 0.691 2.29 0.530 0.581 0.517
KES / CSA, N/cm2 0.703 0.591 0.815 7.25 0.716 0.680 0.412 KES / CSA, N/cm2 0.686 0.573 0.798 6.27 0.757 0.613 0.609
Quality× Quantity Quality× Quantity
CSA × CTV, cm2·HU 0.868 * 0.791 0.945 2678 0.821 0.760 0.039 CSA × CTV, cm2·HU 0.810 * 0.731 0.889 1935 0.719 0.839 0.007
CSA × CTV / height, cm·HU 0.842 0.762 0.923 17.4 0.716 0.880 0.137 CSA × CTV / height, cm·HU 0.782 * 0.698 0.865 12.8 0.692 0.806 0.022
CSA × CTV / height2, HU 0.794 0.705 0.883 0.108 0.629 0.880 0.680 CSA × CTV / height2, HU 0.737 0.647 0.827 0.0843 0.676 0.742 0.116
CSA × CTV / weight, cm2·HU/kg 0.759 0.661 0.856 47.2 0.664 0.760 0.824 CSA × CTV / weight, cm2·HU/kg 0.702 0.606 0.798 37.7 0.697 0.710 0.424
CSA × CTV / BMI, 104·cm4·HU/kg 0.850 0.774 0.926 115 0.843 0.720 0.180 CSA × CTV / BMI, 104·cm4·HU/kg 0.767 0.681 0.853 89.6 0.697 0.742 0.084
Physical performance Physical performance
Grip, kg 0.980 * 0.955 1.000 30.0 0.956 0.920 <0.001 Grip, kg 0.978 * 0.948 1.000 17.9 1.000 0.903 <0.001
KES, N 0.871 * 0.812 0.931 382 0.799 0.800 0.049 KES, N 0.816 * 0.748 0.885 255 0.735 0.710 0.007
Leg Power, W 0.888 0.834 0.943 446 0.769 0.917 0.069 Leg Power, W 0.777 * 0.704 0.850 278 0.737 0.714 0.040
Sit up, times 0.838 0.745 0.931 10.0 0.819 0.783 0.296 Sit up, times 0.692 0.579 0.805 8.00 0.611 0.760 0.732
Walking, m/seconds 0.852 0.767 0.937 1.32 0.764 0.800 0.205 Walking, m/seconds 0.648 0.537 0.760 1.33 0.627 0.613 0.952
Fast walking, m/seconds 0.841 0.747 0.934 1.80 0.777 0.800 0.333 Fast walking, m/seconds 0.739 0.634 0.845 1.67 0.795 0.633 0.277
Balance, seconds 0.772 0.678 0.865 5.00 0.672 0.720 0.969 Balance, seconds 0.794 * 0.717 0.871 5.00 0.632 0.839 0.045
Reaction, seconds 0.784 0.693 0.875 0.479 0.829 0.680 0.877 Reaction, seconds 0.643 0.535 0.751 0.493 0.724 0.516 1.000
Age, years 0.915 * 0.86 0.971 72.0 0.856 0.88 0.007 Age, years 0.828 * 0.748 0.907 67.0 0.757 0.774 0.011

Bold is 0.700 or higher, Red bold is 0.900 or higher.

* Significant higher AUC relative to SMI (p<0.05).

Abbreviations: AUC, area under the curve; CI, confidence interval; CSA, cross-sectional area; BMI, body mass index; ASM, appendicular skeletal muscle mass; SMI, skeletal muscle mass index; CTV, computed tomography attenuation value; HU, Hounsfield unit; KES, knee extension strength.