Table 7.
Validation of diagnostic performance in the external validation cohort.
Men | Sarcopenia | Low muscle mass | Low muscle function | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Specificity | Sensitivity | Accuracy | DOR | Specificity | Sensitivity | Accuracy | DOR | Specificity | Sensitivity | Accuracy | DOR | |
CSA | 0.75 | 0.66 | 0.72 | 5.55 | 0.48 | 0.92 | 0.76 | 9.89 | 0.46 | 0.80 | 0.62 | 3.28 |
CSA/height | 0.55 | 0.82 | 0.64 | 5.23 | 0.54 | 0.92 | 0.79 | 12.64 | 0.33 | 0.82 | 0.56 | 2.12 |
CSA/height2 | 0.53 | 0.84 | 0.63 | 5.57 | 0.60 | 0.91 | 0.80 | 14.15 | 0.30 | 0.77 | 0.53 | 1.42 |
CSA/weight | 0.23 | 0.91 | 0.45 | 2.74 | 0.21 | 0.87 | 0.64 | 1.81 | 0.34 | 0.80 | 0.56 | 2.05 |
CSA/BMI | 0.37 | 0.84 | 0.53 | 3.00 | 0.23 | 0.85 | 0.63 | 1.69 | 0.39 | 0.89 | 0.63 | 4.93 |
ASM | 0.51 | 0.96 | 0.65 | 17.37 | 0.46 | 0.99 | 0.80 | 48.96 | 0.36 | 0.88 | 0.61 | 3.79 |
SMI | 0.57 | 0.96 | 0.70 | 22.59 | – | – | – | – | 0.31 | 0.74 | 0.52 | 1.29 |
ASM/weight | 0.17 | 0.82 | 0.38 | 0.87 | 0.17 | 0.83 | 0.59 | 0.98 | 0.17 | 0.83 | 0.49 | 1.01 |
ASM/BMI | 0.36 | 0.75 | 0.49 | 1.67 | 0.19 | 0.84 | 0.61 | 1.22 | 0.44 | 0.80 | 0.62 | 3.10 |
CTV | 0.11 | 0.96 | 0.39 | 2.19 | 0.06 | 0.98 | 0.65 | 2.63 | 0.13 | 0.95 | 0.53 | 2.76 |
CTV/BMI | 0.20 | 0.75 | 0.38 | 0.73 | 0.00 | 0.67 | 0.43 | 0.02 | 0.47 | 0.68 | 0.57 | 1.85 |
KES/CSA | 0.07 | 0.98 | 0.36 | 2.20 | 0.02 | 0.95 | 0.62 | 0.59 | 0.16 | 0.95 | 0.54 | 3.45 |
CSA*CTV | 0.51 | 0.86 | 0.62 | 6.05 | 0.25 | 0.98 | 0.72 | 11.71 | 0.40 | 0.89 | 0.64 | 5.23 |
CSA*CTV/height | 0.41 | 0.91 | 0.57 | 6.19 | 0.27 | 0.97 | 0.72 | 9.18 | 0.23 | 0.94 | 0.57 | 4.14 |
CSA*CTV/height2 | 0.33 | 0.91 | 0.52 | 4.46 | 0.35 | 0.97 | 0.75 | 13.41 | 0.20 | 0.92 | 0.55 | 2.82 |
CSA*CTV/weight | 0.19 | 0.93 | 0.43 | 2.79 | 0.08 | 0.94 | 0.64 | 1.52 | 0.21 | 0.92 | 0.56 | 3.07 |
CSA*CTV/BMI | 0.33 | 0.86 | 0.50 | 2.94 | 0.17 | 0.85 | 0.61 | 1.16 | 0.40 | 0.88 | 0.63 | 4.54 |
Women | Sarcopenia | Low muscle mass | Low muscle function | |||||||||
Specificity | Sensitivity | Accuracy | DOR | Specificity | Sensitivity | Accuracy | DOR | Specificity | Sensitivity | Accuracy | DOR | |
CSA | 0.55 | 0.95 | 0.62 | 19.86 | 0.47 | 0.97 | 0.62 | 23.61 | 0.47 | 0.81 | 0.65 | 3.86 |
CSA/height | 0.56 | 0.93 | 0.63 | 14.45 | 0.60 | 0.91 | 0.69 | 14.32 | 0.47 | 0.75 | 0.61 | 2.52 |
CSA/height2 | 0.49 | 0.93 | 0.57 | 11.21 | 0.66 | 0.88 | 0.72 | 13.77 | 0.47 | 0.66 | 0.57 | 1.75 |
CSA/weight | 0.47 | 0.58 | 0.49 | 1.23 | 0.30 | 0.75 | 0.44 | 1.30 | 0.43 | 0.78 | 0.61 | 2.64 |
CSA/BMI | 0.30 | 0.84 | 0.40 | 2.11 | 0.18 | 0.90 | 0.39 | 1.83 | 0.63 | 0.76 | 0.70 | 5.42 |
ASM | 0.76 | 0.95 | 0.79 | 51.23 | 0.74 | 0.94 | 0.80 | 41.61 | 0.39 | 0.75 | 0.57 | 1.92 |
SMI | 0.87 | 0.98 | 0.89 | 182.78 | – | – | – | – | 0.52 | 0.53 | 0.52 | 1.19 |
ASM/weight | 0.40 | 0.77 | 0.47 | 2.10 | 0.31 | 0.74 | 0.44 | 1.27 | 0.40 | 0.76 | 0.58 | 2.08 |
ASM/BMI | 0.49 | 0.70 | 0.53 | 2.14 | 0.22 | 0.83 | 0.40 | 1.27 | 0.45 | 0.89 | 0.67 | 6.34 |
CTV | 0.10 | 1.00 | 0.26 | 9.38 | 0.09 | 0.96 | 0.35 | 1.98 | 0.13 | 0.98 | 0.56 | 5.14 |
CTV/BMI | 0.10 | 0.77 | 0.22 | 0.36 | 0.07 | 0.64 | 0.24 | 0.13 | 0.27 | 0.86 | 0.57 | 2.19 |
KES/CSA | 0.21 | 0.91 | 0.34 | 2.38 | 0.07 | 0.96 | 0.33 | 1.43 | 0.19 | 0.94 | 0.57 | 3.62 |
CSA*CTV | 0.25 | 1.00 | 0.39 | 29.82 | 0.19 | 0.99 | 0.43 | 10.86 | 0.33 | 0.92 | 0.63 | 5.20 |
CSA*CTV/height | 0.27 | 1.00 | 0.40 | 31.49 | 0.26 | 0.99 | 0.48 | 16.49 | 0.33 | 0.89 | 0.61 | 3.78 |
CSA*CTV/height2 | 0.29 | 1.00 | 0.42 | 34.99 | 0.33 | 0.99 | 0.52 | 22.11 | 0.30 | 0.86 | 0.59 | 2.66 |
CSA*CTV/weight | 0.27 | 0.88 | 0.38 | 2.53 | 0.17 | 0.90 | 0.38 | 1.68 | 0.36 | 0.90 | 0.63 | 4.81 |
CSA*CTV/BMI | 0.25 | 0.93 | 0.38 | 3.86 | 0.12 | 0.91 | 0.35 | 1.32 | 0.36 | 0.92 | 0.65 | 6.51 |
Abbreviations: DOR, diagnostic odds ratio; CSA, cross-sectional area; BMI, body mass index; ASM, appendicular skeletal muscle mass; SMI, skeletal muscle mass index; CTV, computed tomography attenuation value; HU, Hounsfield unit; KES, knee extension strength