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. 2023 Nov 17;14:1275368. doi: 10.3389/fimmu.2023.1275368

Figure 1.

Figure 1

Primary human CD8+ T cells and NK cells express the IL-2 receptor βγ. (A) Composition of the IL-2 receptor (IL-2R). The IL-2Rα subunit (CD25) alone presents the low-affinity receptor, which lacks signalling capacity du to missing intracellular signalling domains. The intermediate-affinity receptor consists of the IL-2Rβ (CD122) and -γ (CD132) chains and the high-affinity receptor is consitituted of all three subunits. Adapted from (16). (B-E) The mRNA of IL-2Rα, -β, and –γ was quantified via qPCR (B) in freshly isolated CD8+ T cells from buffy coats (N = 5), (C) freshly isolated NK cells (N = 4), (D) primary human hepatocytes (N = 6) and (E) the HepaRG cell line (N = 5). Data are shown as mean ± SEM. QPCR reactions were prepared in technical duplicates and no statistical analyses was performed. NK, natural killer cells; PHHs, primary human hepatocytes; nd, not detectable.