Table 1.
Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of CSA-13, CSA-131, and LL-37 against Staphylococcus aureus Xen29, and Pseudomonas aeruginosa ATCC 27853 and DSM 19880, and two clinical isolates – P. aeruginosa 4B and Ochrobactrum spp. 10B in the presence of NaCl concentration (0–300 mM).
| Compound | NaCl [mM] | MIC/MBC [μg/mL] | ||||
|---|---|---|---|---|---|---|
| Staphylococcus aureus Xen29 | Pseudomonas aeruginosa ATCC 27853 | Pseudomonas aeruginosa PAO1 DSM 19880 | Pseudomonas aeruginosa 4B | Ochrobactrum spp. 10B | ||
| CSA-13 | 0 | 0.5/0.5 | 2/4 | 2/2 | 1/2 | 1/2 |
| 20 | 0.5/0.5 | 2/4 | 2/2 | 1/2 | 1/2 | |
| 60 | 0.5/0.5 | 2/4 | 2/4 | 1/2 | 1/2 | |
| 100 | 0.5/0.5 | 2/4 | 2/4 | 1/2 | 1/2 | |
| 150 | 0.5/0.5 | 2/4 | 2/4 | 1/2 | 1/2 | |
| 300 | 0.5/0.5 | 2/4 | 2/4 | 1/4 | 1/4 | |
| CSA-131 | 0 | 0.5/1 | 2/4 | 1/1 | 2/2 | 0.5/1 |
| 20 | 0.5/1 | 2/4 | 1/1 | 2/4 | 0.5/1 | |
| 60 | 0.5/1 | 2/4 | 1/1 | 2/2 | 0.5/1 | |
| 100 | 0.5/0.5 | 2/4 | 1/2 | 2/2 | 0.5/1 | |
| 150 | 0.5/0.5 | 2/4 | 1/1 | 2/4 | 0.5/0.5 | |
| 300 | 0.5/0.5 | 2/4 | 1/1 | 2/4 | 0.5/1 | |
| LL-37 | 0 | >256/>256 | 128/128 | 16/32 | 128/128 | 8/16 |
| 20 | -* | - | 16/64 | - | 8/32 | |
| 60 | - | - | 16/64 | - | 8/32 | |
| 100 | - | - | 32/64 | - | 16/32 | |
| 150 | - | - | 64/128 | - | 16/64 | |
| 300 | - | - | 128/>256 | - | 64/>256 | |
* - not determined.