Table 2.
Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values of CSA-13, CSA-131, and omiganan against Candida albicans ATCC 10231, and two clinical isolates – C. albicans 12B and C. tropicalis 178 in the presence of NaCl concentration (0–300 mM).
| Compound | NaCl [mM] | MIC/MFC [μg/mL] | ||
|---|---|---|---|---|
| Candida albicans ATCC 10231 | Candida albicans 12B | Candida tropicalis 178 | ||
| CSA-13 | 0 | 4/4 | 4/4 | 0.25/0.5 |
| 20 | 4/4 | 4/4 | 0.25/0.25 | |
| 60 | 4/4 | 4/4 | 0.5/0.5 | |
| 100 | 4/4 | 4/4 | 0.5/0.5 | |
| 150 | 4/8 | 4/4 | 0.5/0.5 | |
| 300 | 4/8 | 4/4 | 0.5/0.5 | |
| CSA-131 | 0 | 1/1 | 2/2 | 0.5/0.5 |
| 20 | 1/1 | 2/2 | 0.5/0.5 | |
| 60 | 1/2 | 2/2 | 0.5/0.5 | |
| 100 | 1/1 | 2/2 | 0.5/0.5 | |
| 150 | 1/2 | 2/2 | 0.5/0.5 | |
| 300 | 1/1 | 2/2 | 0.5/0.5 | |
| Omiganan | 0 | >256/>256 | >256/>256 | 16/32 |
| 20 | -* | - | 16/32 | |
| 60 | - | - | 16/32 | |
| 100 | - | - | 16/32 | |
| 150 | - | - | 32/64 | |
| 300 | - | - | 64/128 | |
* - not determined.