Table 3.

Multivariable logistic regression model for csPCa detection rate on target biopsy (csCDR-T), per-centre and per-operator

csCDR-T-multivariable regression	Centre 1	Centre 2	Operator 1	Operator 2	Operator 3	Operator 4b
Age
OR	1.082	1.081	1.045	1.176	1.004	1.332
p	0.001	0.001	0.48	0.003	0.95	0.042
Centre experience
OR	1.002	1.004	-	-	-	-
p	0.088	0.001
Operator experience
OR	-	-	0.999	1.023	0.984	1.037
p			0.984	0.075	0.427	0.094
PSA density [ng/mL/cc]
OR	222.952	43.973	0.722	3.120.352	46.474	2.840.006
p	0.002	0.001	0.926	0.043	0.237	0.057
Prostate volume [cc]
OR	0.979	0.98	0.946	0.99	0.97	0.955
p	0.001	0.024	0.019	0.407	0.402	0.266
Positive DRE
OR	2.376	2.954	5.297	5.643	1.961	26.384
p	0.002	0.001	0.039	0.013	0.555	0.027
PI-RADS 4 lesiona
OR	3.861	5.224	1.73	5.383	3.709	3.997
P	0.001	0.001	0.633	0.05	0.314	0.451
PI-RADS 5 lesiona
OR	3.314	8.444	71.576	3.931	2.084	237.558
p	0.025	0.001	0.037	0.213	0.671	0.014
Target diameter [mm]
OR	1.157	1.009	0.837	1.245	1.087	0.887
p	0.001	0.752	0.161	0.01	0.353	0.294
Positive family history
OR	0.812	3.822	0.211	0.825	-	61.396
p	0.587	0.023	0.224	0.809		0.008

The 95% confidence intervals for this table are shown in Supplementary Table 6B

Significant p values (below 0.05) are in bold

DRE digital rectal examination, PI-RADS Prostate Index Reporting and Data System score, OR odds ratio

^aReference is PI-RADS 3 lesion

^bFirth procedure for logistic regression used for Operator 4