Table 2.
Concentrations selected to perform the metabolomics experiments based on range finder experiments
| Substance | EC1 (μM) | EC5 (μM) | EC15 (μM) | EC50 (μM) | EC85 (μM) |
|---|---|---|---|---|---|
| Bezafibratea | 1000 | ||||
| Acifluorfen | 50 | 100 | 200 | 500 | 800 |
| Wy-14643 | 25 | 50 | 150 | 500 | 1000 |
| β-naphthoflavone | 0.1 | 1 | 10 | 100 | 700 |
| Aroclor 1254 | 21 | 38 | 56 | 94 | 133 |
| Pendimethalin | 24 | 39 | 56 | 94 | 157 |
| Ketoconazole | 5b | 0.2 | 1 | 10 | 50 |
aBezafibrate 1000 μM was used as positive control in each experiment
bFor Ketoconazole, the EC1 was excluded and a concentration between the EC15 and EC50 was selected instead. ECs were estimated based on the ATP dose response curves generated in the range finder experiments