Table 2.
Toxic profile of reference concentrations of ETC inhibitors including relative in vivo LD50s and IVIVE of equivalent administered doses in humans
| Complex inhibited | Compound name | Acute toxicity category | Reference concentration (µM) | LD50 mg/kg (acute oral/rats) | EAD50 mg/kg/dose (human) |
|---|---|---|---|---|---|
| CI | Capsaicin | II | 1.00E + 02 | 148.10 | 3.12E + 01 |
| CI | Deguelin | NA | 8.00E − 02 | NA | 3.14E − 02 |
| CI | Fenpyroximate | II | 1.60E − 02 | 245.00 | 5.99E − 03 |
| CI | Pyrimidifen | II | 1.60E − 02 | 115.00 | 5.84E − 03 |
| CI | Rotenone | I | 6.40E − 04 | 70.75 | 2.38E − 04 |
| CI | Tebufenpyrad | II | 1.00E + 01 | 202.00 | 2.98E + 00 |
| CII | Carboxine | III | 2.00E + 02 | 2588.00 | 8.31E + 01 |
| CII | Mepronil | IV | 5.00E + 02 | > 10,000 | 1.30E + 02 |
| CII | Thifluzamide | IV | 2.70E + 02 | > 6500 | 1.28E + 02 |
| CIII | Antimycin A | II | 2.56E − 05 | 323.50 | NA |
| CIII | Azoxystrobin | IV | 1.00E + 01 | > 5000 | 5.54E + 00 |
| CIII | Picoxystrobin | IV | 2.00E + 00 | > 5000 | 8.31E − 01 |
| CIII | Pyraclostrobin | IV | 4.00E − 01 | > 5000 | 1.49E − 01 |
Data represent 24 h exposure of a single dose of the drug