Table 2.
Weight at breast cancer diagnosis and weight change 1 year and 5 years post-diagnosis.
| Weight at dx, mean kg (se)a,b | p-value | Weight change in kg, dx to 1 yearb | p-value | Weight change in kg, dx to 5 yearsb | p-value | |
|---|---|---|---|---|---|---|
| Age at diagnosis, years | ||||||
| ≤45 | 71.9 (0.9) | Ref. | +1.00 (0.05) | Ref. | +1.75 (0.10) | Ref. |
| 45–55 | 75.9 (0.7) | <0.001 | +0.25 (0.03) | <0.001 | +0.83 (0.07) | <0.001 |
| 55–70 | 77.1 (0.7) | <0.001 | −0.09 (0.02) | <0.001 | −0.93 (0.05) | <0.001 |
| ≥70 | 73.6 (0.7) | 0.06 | −0.91 (0.04) | <0.001 | −4.34 (0.08) | <0.001 |
| BMI group at diagnosis, kg/m2 | ||||||
| ≤18.5 | 44.7 (1.2) | <0.001 | +0.61 (0.15) | 0.95 | +3.24 (0.34) | <0.001 |
| 18.5–25 | 57.1 (0.4) | Ref. | +0.61 (0.03) | Ref. | +1.95 (0.07) | Ref. |
| 25–30 | 69.4 (0.4) | <0.001 | +0.28 (0.03) | <0.001 | −0.27 (0.06) | <0.001 |
| 30–35 | 82.1 (0.4) | <0.001 | −0.32 (0.03) | <0.001 | −2.00 (0.08) | <0.001 |
| ≥35 | 100.9 (0.4) | <0.001 | −1.01 (0.04) | <0.001 | −4.50 (0.08) | <0.001 |
| Race and ethnicity | ||||||
| Non-Hispanic white | 74.2 (0.5) | Ref. | +0.09 (0.02) | Ref. | −0.65 (0.04) | Ref. |
| Non-Hispanic Black | 84.2 (0.9) | <0.001 | −0.58 (0.05) | <0.001 | −1.95 (0.11) | <0.001 |
| Hispanic | 74.3 (1.0) | 0.92 | −0.10 (0.06) | 0.002 | −0.64 (0.13) | 0.93 |
| Other/unknown | 68.0 (1.2) | <0.001 | −0.44 (0.09) | <0.001 | −1.02 (0.18) | 0.05 |
| Clinical stage at diagnosis | ||||||
| Stage I | 75.0 (0.6) | Ref. | −0.03 (0.02) | Ref. | −0.84 (0.05) | Ref. |
| Stage II | 75.0 (0.7) | 0.95 | +0.02 (0.03) | 0.25 | −0.65 (0.06) | 0.02 |
| Stage III | 75.6 (1.1) | 0.56 | −0.14 (0.06) | 0.06 | −0.03 (0.12) | <0.001 |
| Unknown | 74.4 (1.1) | 0.58 | +0.25 (0.09) | 0.003 | −4.10 (0.21) | <0.001 |
| Tumor subtype | ||||||
| ER/PR+, HER2− | 75.0 (0.7) | Ref. | −0.01 (0.02) | Ref. | −0.90 (0.04) | Ref. |
| ER/PR+, HER2+ | 72.4 (1.1) | 0.01 | +0.55 (0.05) | <0.001 | +0.85 (0.11) | <0.001 |
| ER/PR−, HER2+ | 75.1 (1.4) | 0.93 | +0.75 (0.07) | <0.001 | +4.90 (0.59) | <0.001 |
| TNBC | 76.4 (1.0) | 0.24 | −0.60 (0.05) | <0.001 | −1.63 (0.11) | <0.001 |
| Unknown | 75.6 (0.8) | 0.49 | −0.45 (0.07) | <0.001 | −1.96 (0.15) | <0.001 |
| Chemotherapy | ||||||
| No | 75.0 (0.7) | Ref. | −0.17 (0.02) | Ref. | −1.90 (0.05) | Ref. |
| Yes | 75.0 (0.6) | 0.97 | +0.11 (0.02) | <0.001 | +0.20 (0.05) | <0.001 |
| Radiation | ||||||
| No | 73.5 (0.6) | Ref. | −0.04 (0.03) | Ref. | −0.91 (0.06) | Ref. |
| Yes | 76.4 (0.6) | <0.001 | 0.00 (0.02) | 0.30 | −0.76 (0.04) | 0.04 |
Dx diagnosis, BMI body mass index, TNBC Triple-negative breast cancer.
aWeight at dx is based on having a first weight within 6 months of dx.
bAdjusted for Age at diagnosis (continuous), Race and ethnicity, Tumor subtype (ER/PR+, HER2−; ER/PR+, HER2+; ER/PR−, HER2+, TNBC), Clinical stage, Chemotherapy (yes/no), Radiation (yes/no), Endocrine therapy (yes/no).