Figure 10.

Nanomaterials in combinational BC therapies. a) Schematic illustration of the preparation of NRGO-GNS@DOX nanocomposite for combined photothermal and chemotherapy of BC, including internalization, entrapment inside the lysosome, and cytosol release of DOX under NIR irradiation (inside (a), (b), and (c), respectively), b) numbers of lung metastasis nodules, and c) staining of the lung in mice treated with various samples (i.e., 1. PBS, 2. NRGO-GNS, 3. DOX, 4. NRGO-GNS@DOX, 5. NRGO-GNS+laser, 6. NRGO-GNS@DOX+laser) (**p < 0.01). Reproduced with permission.^[213] Copyright 2016, John Wiley and Sons, d) illustration of graphene quantum dot-based theranostic agent for probing anticancer drug delivery, release, and response, and e) images of multicellular 3D tumor spheroids. Reproduced with permission.^[214] Copyright 2017, American Chemical Society.