Table 2.

Comparison of the in vitro activity of two DHODH inhibitors, olorofim and ipflufenoquin against Aspergillus species determined according to the EUCAST E.Def 9.4 with a complete inhibition endpoint and by applying a partial (50%) growth inhibition endpoint.

Inhibition endpoint criteria and species (n)	Olorofim MIC (mg/L)												Ipflufenoquin MIC (mg/L)
0.002	0.004	0.008	0.016	0.03	0.06	0.125	0.25	0.5	1	2	> 4	0.06	0.125	0.25	0.5	1	2	4	8	16	32	> 32
Visual complete inhibition
A. sydowii (2)		1	1									2
A. flavus SC (2)		1	1										1	1
A. terreus SC (2)			2												1	1
A. fumigatus SC* (5)			1	1	3												1**	1**	1	2
A. nidulans SC (2)					2											2
A. niger SC (2)				1	1																2
A. calidoustus (2)							2								2
Section Aspergillus# (4)												4								1		3
Spec. 50% inhibition
A. sydowii (2)		1	1									1	1
A. flavus SC (2)	1		1										2
A. terreus SC (2)	1	1										1				1
A. fumigatus SC * (5)			1	4												4		1
A. nidulans SC (2)				2											1	1
A. niger SC (2)				1	1																2
A. calidoustus (2)							1	1							1	1
Section Aspergillus# (4)												4						1##				3

^#One A. montevidensis, one A. chevalieri, two A. intermedius.

^##one A. chevalieri.

^*Two A. fumigatus Cyp51A wild-type, one A. fumigatus Cyp51A TR₃₄/L98H, and two A. hiratsukae.

^**Two A. hiratsukae.