Table 1.

Summary of human γS dynamics parameters measured by NMR.

	WT	N14D	N76D
Number of fast exchanging residues (kex ≥ 500 sec−1*10−6)a	34	38	40
Number of intermediate exchanging residues (0.1 ≤ kex ≤ 500 sec−1*10−6)b	57	55	78
Number of slow exchanging core residues (kex < 0.1 sec−1*10−6)c	36	35	9
(R2/R1)d	25.6 ± 0.4	26.0 ± 0.9	23.3 ± 1.2
Number of Rex terms e	10	37	7
(S2)f	0.86 ± 0.02	0.82 ± 0.02	0.86 ± 0.02
NOE g	0.82 ± 0.01	0.79 ± 0.01	0.8 ± 0.03

^{a, b, c}Derived from CLEANEX and H/D exchange data presented in Figure 6.

^dAverage R₂/R₁ values derived from data presented in Figure 7B.

^eNumber of R_ex terms. N14D R_ex terms are mapped onto the γS structure in Figure 8A.

^fAverage S² values derived from data presented in Figure 8B, C.

^gAverage NOE values derived from data presented in Figure S6