Table 1. Results of the in vitro susceptibility of 10 Sporothrix brasiliensis isolates to amlodipine (AML) and lufenuron (LUF) in combination with itraconazole (ITZ).
| MICa | INb | MIC | INb | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| FURG ID | Source | AML alone | AML comb | ITZ alone | ITZ comb | LUF alone | LUF comb | ITZ alone | ITZ comb | ||
| 716 | RS | 64 | 32 | 1 | 0.25 | WS | >64 | 16 | 1 | 0.5 | WS |
| 1078 | RS | 32 | 8 | 1 | 0.5 | WS | >64 | >64 | 1 | 1 | IND |
| 1878 | RS | 64 | 8 | 0.5 | 0.125 | SS | >64 | >64 | 0.5 | 0.5 | IND |
| 3952 | RS | 64 | 64 | >8 | >8 | IND | >64 | >64 | >8 | >8 | IND |
| 5150 | RS | 64 | 32 | 1 | 0.25 | WS | >64 | 16 | 1 | 0.5 | WS |
| 9011 | RJ | 64 | 64 | 0.5 | 0.5 | IND | >64 | >64 | 0.5 | 0.5 | IND |
| 9013 | RJ | 32 | 32 | 1 | 1 | IND | >64 | 4 | 1 | 0.5 | WS |
| 9014 | RJ | 128 | 128 | >8 | >8 | IND | >64 | >64 | >8 | >8 | IND |
| 9015 | RJ | 32 | 8 | 0.5 | 0.25 | WS | >64 | 1 | 0.5 | 0.25 | WS |
| 9017 | ATCC | 64 | 32 | 1 | 0.5 | AD | >64 | >64 | 1 | 1 | IND |
Notes.
- FURG ID
- Isolate identification of Universidade Federal do Rio Grande
- MIC
- Minimal inhibitory concentration
- comb
- MIC of each drug when used in combination
- IN
- Interpretation
a
MIC expressed as µg/mL.
b
IN: <0.5 strong synergism (SS); 0.5–<1 weak synergism (WS); 1–<2 additive (AD); 2 indifferent (IND); >2 antagonism (AN).