Table 2.
Multivariate Cox logistic regression analysis of PFS and OS for 395 patients with ccRCC from the FUSCC and external validation cohorts
| FUSCC training cohort (n=290) | External validation cohort (n=105) | |||
| HR (95% CI) | P value | HR (95% CI) | P value | |
| PFS | ||||
| Age | 1.003 (0.99 to 1.017) | 0.646 | 1.008 (0.986 to 1.03) | 0.487 |
| Pathological T stage (ref. T1/T2） |
1.728 (1.182 to 2.526) | 0.005* | 2.148 (1.051 to 4.391) | 0.036 |
| Pathological M stage (ref. M0) |
4.189 (2.768 to 6.339) | <0.001 | 4.279 (1.736 to 10.544) | 0.002 |
| ISUP grade (ref. G1/G2) |
1.696 (1.24 to 2.321) | 0.001 | 2.127 (1.082 to 4.184) | 0.029 |
| Tumor-proximal TLS (ref. absence） |
0.426 (0.198 to 0.916) | 0.029 | 0.252 (0.073 to 0.868) | 0.029 |
| Tumor-distal TLS (ref. absence） |
1.25 (0.859 to 1.818) | 0.243 | 1.237 (0.653 to 2.343) | 0.514 |
| OS | ||||
| Age | 1.006 (0.992 to 1.021) | 0.417 | 1.034 (1.005 to 1.065) | 0.023 |
| Pathological T stage (ref. T1/T2） |
1.807 (1.203 to 2.715) | 0.004 | 5.953 (2.405 to 14.736) | <0.001 |
| Pathological M stage (ref. M0) |
4.659 (2.994 to 7.25) | <0.001 | 4.323 (1.397 to 13.38) | 0.011 |
| ISUP grade (ref. G1/G2) |
1.463 (1.044 to 2.048) | 0.027 | 2.077 (0.897 to 4.806) | 0.088 |
| Tumor-proximal TLS (ref. absence） |
0.33 (0.121 to 0.898) | 0.030 | 0.103 (0.012 to 0.891) | 0.039 |
| Tumor-distal TLS (ref. absence） |
1.137 (0.764 to 1.693) | 0.526 | 0.859 (0.342 to 2.155) | 0.745 |
*P value<0.05 is marked in bold.
.ccRCC, clear cell renal cell carcinoma; FUSCC, Fudan University Shanghai Cancer Center; ISUP, International Society of Urological Pathology; OS, overall survival; PFS, progression-free survival; TLS, tertiary lymphoid structures.