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Pro-survival proteins and apoptosis in acute myeloid leukemia.
MCL-1 and BCL-2 are pro-survival proteins that are frequently targeted or dysregulated in AML. Venetoclax is a BCL-2 inhibitor that results in apoptosis through mitochondrial cytochrome C release. BCL-2 resistance can occur through up-regulation of MCL-1, which can be overcome through suppression of the RAS pathway by p53.
