Table 1.

Major regulators of epigenetics in AML.

Role in epigenetics	Implicated proteins or molecules
DNA methylation	• DNMT family
DNA demethylation	• TET family • IDH1/2 (via supporting catalytic function of TET proteins)
Histone methylation	• EZH2 • KMT2A (MLL) • DOT1L
Histone demethylation	• LSD1 (reviewed elsewhere)
Histone acetylation	• Histone acetyltransferases
Histone deacetylation	• Histone deacetylases (HDACs)
Histone deubiquitiniation	• ASXL1 • BAP1
MicroRNA	• miR-9 (reviewed elsewhere)