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Clinical trials in IDH1mat or IDH2mat AML.
| Mutation | Study regimen | Trial identifier |
|---|---|---|
| IDH1mut or IDH2mut | AML | |
| IDH1 mut | Ivosidenib or placebo + azacitidine | NCT03173248 |
| IDH1 mut | Ivosidenib and CPX-351 | NCT04493164 |
| IDH1 mut | Olutasidenib with azacitidine or cytarabine | NCT02719574 |
| IDH2 mut | Enasidenib and venetoclax | NCT04092179 |
| IDH1mut or IDH2mut | Ivosidenib or enasidenib with 7 + 3 followed by cytarabine or mitoxantrone/etoposide consolidation | NCT02632708 |
