Table 5.
Change in the correct choice latency after 2MDHX and CY208 were administered at their optimal or detrimental dose, respectively
| Vehicle | 2MDHX | CY208 | |||||
|---|---|---|---|---|---|---|---|
| Optimal | Detrimental | Optimal | Detrimental | ||||
| Time to make correct choices (S) | Mean ± SD | 7.9 ± 4.5 | 7.3 ± 8.8 | 15.6 ± 13.3 | 8.5 ± 7.8 | 6.3 ± 7.6 | |
| Vehicle | x | 0.839 | 0.130 | 0.823 | 0.560 | ||
| 2MDHX | Optimal | 0.839 | x | 0.136 | 0.736 | 0.798 | |
| Detrimental | 0.130 | 0.136 | x | 0.185 | 0.089 | ||
| CY208 | Optimal | 0.823 | 0.736 | 0.185 | x | 0.515 | |
| Detrimental | 0.560 | 0.798 | 0.089 | 0.515 | x | ||
| CV (%) | 103 ± 28 | 128 ± 53 | 86 ± 54 | 115 ± 56 | 106 ± 58 | ||
| Vehicle | x | 0.228 | 0.4 | 0.545 | 0.875 | ||
| 2MDHX | Optimal | 0.228 | x | 0.115 | 0.596 | 0.395 | |
| Detrimental | 0.4 | 0.115 | x | 0.258 | 0.43 | ||
| CY208 | Optimal | 0.545 | 0.596 | 0.258 | x | 0.731 | |
| Detrimental | 0.875 | 0.395 | 0.43 | 0.731 | x | ||
CV indicates trial-to-trial variation. p values of pairwise comparisons are reported on the rows under the mean ± SD or CV. Least significant difference was used for multiple comparisons adjustment. Note 2MDHX caused slightly longer correct choice latency compared to CY208 when they were administered at their detrimental doses respectively. x, not tested or not applicable