TABLE 3.

The heterogeneity and horizontal pleiotropy tests in the MR analysis.

Exposure	Outcome	Heterogeneity test				Horizontal pleiotropy test
		MR–Egger		IVW
		Cochran's Q	p value	Cochran's Q	p value	Egger‐intercept	p value
SHBG	Pathological fracture with osteoporosis	227.32	0.05	228.57	0.05	5.68E‐03	0.30
	Fracture of lumbar spine and pelvis	258.76	1.10E‐03	261.32	9.05E‐04	−4.17E‐03	0.17
	Fracture of ribs, sternum and thoracic spine	196.37	0.40	196.43	0.42	−5.36E‐04	0.81
	Fracture of neck	184.06	0.63	184.15	0.65	−1.57E‐03	0.77
	Fracture of skull and facial bones	234.90	0.02	235.21	0.02	1.36E‐03	0.62
	Fracture of femur	219.85	0.08	222.01	0.07	−3.27E‐03	0.17
	Fracture of lower leg, including ankle	251.94	2.39E‐03	252.44	2.60E‐03	1.04E‐03	0.54
	Fracture of foot, except ankle	208.92	0.19	210.11	0.19	2.59E‐03	0.30
	Fracture of shoulder and upper arm	251.79	2.44E‐03	252.46	2.60E‐03	1.55E‐03	0.48
	Fracture of forearm	269.55	1.56E‐04	269.84	1.80E‐04	−8.09E‐04	0.65
	Fracture at wrist and hand level	220.52	0.07	220.77	0.08	−9.68E‐04	0.64
BT	Pathological fracture with osteoporosis	61.40	0.32	62.38	0.32	1.21E‐02	0.34
	Fracture of lumbar spine and pelvis	79.09	0.03	79.13	0.03	1.16E‐03	0.88
	Fracture of ribs, sternum and thoracic spine	65.80	0.20	66.04	0.22	2.56E‐03	0.65
	Fracture of neck	54.12	0.58	56.95	0.51	2.14E‐02	0.10
	Fracture of skull and facial bones	63.83	0.25	63.96	0.28	2.12E‐03	0.74
	Fracture of femur	65.80	0.20	66.04	0.22	2.56E‐03	0.65
	Fracture of lower leg, including ankle	64.03	0.24	67.67	0.18	−6.73E‐03	0.08
	Fracture of foot, except ankle	58.98	0.40	59.78	0.41	−5.10E‐03	0.38
	Fracture of shoulder and upper arm	86.36	7.29E‐03	86.76	8.56E‐03	2.90E‐03	0.61
	Fracture of forearm	101.29	2.77E‐04	104.53	1.75E‐04	6.42E‐03	0.18
	Fracture at wrist and hand level	85.58	8.48E‐03	86.03	9.85E‐03	3.10E‐03	0.59

Abbreviation: MR, Mendelian randomization.