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. 2023 Nov 20;14:1273182. doi: 10.3389/fimmu.2023.1273182

Figure 1.

Figure 1

STAT3 deficiency in basal keratinocytes exacerbated DNCB-induced AD-like skin inflammation. (A) Schematic diagram of the experimental design of DNCB-induced AD-like skin inflammation. (B, D) Representative phenotypes and histological changes in Stat3f/f mice and Stat3 cKO mice after DNCB or vehicle treatment on Day 21. Bar = 250 μm. (C) During the induction period, ear thickness (mm) was measured weekly (n ≥ 10). (E) Representative IHC staining of Ki67 and (F) Ki67-positive keratinocyte counts (n = 5-6). Bar = 50 μm. The data are presented as the mean ± SD, *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.