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. 2023 Nov 20;14:1273182. doi: 10.3389/fimmu.2023.1273182

Figure 2.

Figure 2

Epidermal barrier dysfunction was aggravated in Stat3 cKO mice with AD-like skin inflammation, accompanied by AMP insufficiency and microbial dysbiosis. (A) Representative IF staining of filaggrin, loricrin, S100A9, and LL37 (red) in the ear skin of Stat3f/f mice and Stat3 cKO mice after DNCB or vehicle treatment. Bar = 50 μm. (B, C) The microbial diversity on the surface of the ear skin and the relative abundance of different microbial genera determined by full-length 16s ribosomal RNA sequencing (n = 4-5). (D) KEGG pathway analysis of differentially expressed genes identified by RNA sequencing between the epidermis of Stat3f/f mice and Stat3 cKO mice after DNCB treatment (n = 3-4, adjusted P < 0.05, |log2-fold change| > 2).