Table 2.
Correlation of mRNA expression levels of eight antimicrobial genes with CC16 in bronchial epithelial cells in SARP.
| Mouse Protein | Human Gene | Cross-Sectional Cohort (n = 155) |
Longitudinal Cohort (n = 156) |
Meta-Analysis* | |||
|---|---|---|---|---|---|---|---|
| rho | P value | rho | P value | rho | P value | ||
| CC16 | SCGB1A1 | – | – | – | – | – | – |
| BPIA1_SPLUNC1 | BPIFA1 | 0.19 | 0.017 | 0.19 | 0.021 | 0.19 | 2.9x10-4 |
| BPIB1 | BPIFB1 | -0.071 | 0.38 | -0.14 | 0.073 | -0.11 | 0.027 |
| TRFE | TF | 0.028 | 0.73 | 0.24 | 0.003 | 0.13 | 0.009 |
| TRFL | LTF | 0.51 | 1.3x10-11 | 0.55 | <2.2x10-16 | 0.53 | 1.6x10-39 |
| SCGB3A2 | SCGB3A2 | 0.23 | 0.003 | 0.018 | 0.82 | 0.13 | 0.012 |
| PSPB | SFTPB | -0.027 | 0.74 | 0.022 | 0.78 | -0.002 | 0.48 |
| SFTPD | SFTPD | 0.19 | 0.019 | 0.034 | 0.67 | 0.11 | 0.024 |
| LYZ2 | LYZ | -0.062 | 0.44 | -0.17 | 0.034 | -0.12 | 0.019 |
*Meta-analysis of Spearman correlation coefficient (rho) was performed in the SARP cohorts (n=311) using metacor R package on the Olkin-Pratt fixed-effect meta-analytical model.