Table 2.
Classification1 | Factor | Median (IQR) 1 | p-value2 | |
---|---|---|---|---|
Case n=16 |
Control n=51 |
Case vs Control | ||
Pro-/anti-inflammatory | IFNγ | 3.0 (2, 7) | 2.18 (1.5, 3.2) | 0.068 |
GM-CSF | 0.001 (0, 0.07) | 0.07 (0, 0.12) | 0.03* | |
IL10 | 0.35 (0.29, 0.68) | 0.29 (0.21, 0.42) | 0.03* | |
IL2 | 0.11 (0.07, 0.22) | 0.15 (0.09, 0.18) | 0.7 | |
Chemokine | Eotaxin | 213 (19, 338) | 269 (216, 372) | 0.087 |
Eotaxin3 | 21 (17, 25) | 20 (15, 29) | 0.05* | |
IL16 | 244 (204, 271) | 208 (167, 246) | 0.074 | |
IL8 | 0 (0,0) | 2 (0, 67) | 0.006* | |
MCP4 | 88 (72, 150) | 115 (90, 115) | 0.1 | |
MIP1β | 114 (77, 152) | 136 (105, 158) | 0.2 | |
Th17 | IL17A | 2.64 (1.60, 3.04) | 1.72 (1.20, 2.39) | 0.018* |
IL17AF | 0 (0, 0.1) | 0.001 (0, 0.3) | 0.6 | |
IL17B | 0.31 (0.14, 0.44) | 0.67 (0.31, 0.97) | 0.016* | |
IL17C | 0 (0, 0.1) | 0.00 (0.00, 0.00) | >0.9 | |
Vascular Injury | CRP | 2,162,710 (862,164, 7,718,677) |
520,619 (284,546, 1,538,951) |
0.014* |
ICAM1 | 68,440 (463,980, 698,292) |
391,945 (323,475, 593,272) |
0.004* | |
VCAM1 | 612,265 (540,375, 752,649) |
425,374 (355,599, 578,439) |
<0.001* | |
SAA | 1,928,395 (1,323,845, 5,521,066) |
1,279,690 (751,070, 2,022,183) |
0.045* | |
Angiogenesis | Flt1 | 118 (111, 145) | 142 (128, 180) | 0.022* |
VEGF | 343 (139, 377) | 139 (82, 202) | 0.013* | |
VEGF-C | 529 (486, 578) | 533 (496, 690) | 0.4 | |
Growth Factors | TSLP | 0 | 0 | 0.4 |
IL7 | 13.7 (9.9, 18.0) | 15.1 (11.2, 18.6) | 0.7 |
1Factors grouped based on their biological functions. 2Data expressed as pg/ml serum cytokine concentration; 3p-value from Wilcoxon signed rank test. Asterisk ( * ) indicates statistical significance.