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. 2023 Nov 20;10:1256997. doi: 10.3389/fvets.2023.1256997

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Copyright © 2023 Crosby, Karisch, Hiott, Pinnell, Pittman, Frye, Jackson, Loy, Epperson, Blanton, Capik, Morley and Woolums.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Maximum likelihood tree of pangenome of all MH isolated. Numbers indicate ultrafast bootstrap values generated from 1000 replicates; values less than 85 are not shown. Outlines indicate clustered isolates. MH, Mannheimia haemolytica; TxGroup, treatment group; AM Before, treated with antimicrobial before isolation; MALDI, MALDI biomarker genotype; F19, Fall 2019; F20, Fall 2020; S21, Spring 2021; F21, Fall 2021; META, tulathromycin metaphylaxis; NO META, no tulathromycin metaphylaxis; ICE, integrative conjugative element; Y, Yes; N, No; WK3, week 3; WK10, week 10; Rem, isolate from animal removed from study; MDR, Multidrug Resistant. Reference- Mannheimia haemolytica USDA-ARS-USMARC-191 (GenBank: CP023044.1).