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. 2023 Nov 20;10:1256997. doi: 10.3389/fvets.2023.1256997

Table 6.

Animal health from arrival to 3 weeks.

Trial TxGroup n ADG (95% CI) (kg) Animals treated n (%)# BRD morbidity n (%)# Crude mortality n (%)
Fall 2019 META 41 1.48 (1.20–1.77)d 11 (27) 9 (22) 0 (0)
NO META 41 1.00 (0.66–1.30)e 9 (22) 7 (17) 0 (0)
All 82 1.21 (0.83–1.65)j 20 (24) 16 (20) 0 (0)
Fall 2020 META 42 0.54 (0.22–1.08)f 6 (19) 6 (14) 1 (2)
NO META 41 0.22 (−0.22–0.70)g 11 (27) 10 (24) 2 (5)
All 83 0.43 (−0.11–0.97)k 17 (20) 16 (19) 3 (4)
Spring 2021 META 42 0.88 (0.34–1.27) 5 (10)m 4 (10)q 2 (5)
NO META 40 0.69 (0.22–1.37) 18 (42)n 17 (44)r 4 (10)
All 82 0.83 (0.26–1.34)l 23 (26) 21 (26) 6 (7)
Fall 2021 META 42 1.02 (0.57–1.49)h 2 (2)o 1 (2)s 0 (0)
NO META 42 0.78 (−0.02–1.13)i 12 (29)p 12 (29)t 1 (2)
All 84 0.91 (0.34–1.23)l 14 (16) 13 (16) 1 (1)
Overall META 167 1.02 (0.43–1.49) 24 (15) 20 (12) 3 (2)
NO META 164 0.70 (0.16–1.18) 50 (29) 46 (28) 7 (4)
All 331 0.89 (0.30–1.34)*a 74 (22)*b 66 (20)*c 10 (3)

An asterisk (*) in the ‘Overall’ row represents that there was an overall statistical difference between META and NO META TxGroups (a, Wilcoxon Sum Rank test, p = 0.0002; b, χ2 test, p = 0.0007; c, χ2 test, p = 0.004). Values with different superscripts in the same column of the ‘META’ or ‘NO META’ rows represent a statistical difference between TxGroups within Trial (d-i, Wilcoxon Sum Rank, p ≤ 0.05; m-p and q-t, χ2 test, p ≤ 0.05). Values with different superscripts in the same column of the ‘All’ rows represent a statistically significant difference among Trials (j-l, Kruskal Wallis Analysis of Variance on Ranks with post-hoc Dunn Test and Benjamini Hochberg Correction, p ≤ 0.05). Percentages represent percent of animals. #There was a significant difference between animals treated with antimicrobials and animals treated for BRD (McNemar’s χ2 Test, p = 0.01). TxGroup, treatment group; MH, Mannheimia haemolytica; MDR, multi-drug resistant; CI, confidence interval; ADG, average daily gain; BRD, bovine respiratory disease; META, tulathromycin metaphylaxis; NO META, no tulathromycin metaphylaxis.