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. 2023 Nov 20;10:1256997. doi: 10.3389/fvets.2023.1256997

Table 8.

Week 10 health data.

Trial TxGroup n Median-ADG (95% CI) (kg) Animals treated n (%)# BRD Morbidity n (%)# Mortality n (%)
Fall 2019 META 41 0.96 (0.87–1.17)d 11 (27) 9 (22) 0 (0)
NO META 41 0.88 (0.71–0.95)e 11 (27) 9 (22) 0 (0)
All 82 0.92 (0.79–1.08)j 22 (27) 18 (22) 0 (0)
Fall 2020 META 42 0.82 (0.64–0.92)f 9 (21) 7 (17) 2 (5)
NO META 41 0.65 (0.42–0.86)g 12 (29) 10 (24) 2 (5)
All 84 0.78 (0.49–0.91)k 21 (25) 17 (20) 4 (5)
Spring 2021 META 42 0.76 (0.61–0.97) 5 (12)m 4 (10)o 4 (10)
NO META 40 0.73 (0.52–0.88) 18 (45)n 17 (43)p 7 (18)
All 82 0.76 (0.53–0.94)k 23 (28) 21 (26) 11 (13)
Fall 2021 META 42 0.45 (0.33–0.71)h 6 (14) 4 (10)q 0 (0)
NO META 42 0.38 (0.19–0.57)i 14 (33) 14 (33)r 2 (5)
All 84 0.44 (0.25–0.62)l 20 (24) 18 (21) 2 (2)
Overall META 167 0.80 (0.51–0.97) 31 (19) 24 (14) 6 (4)
NO META 164 0.64 (0.44–0.89) 55 (34) 50 (30) 11 (7)
All 331 0.74 (0.45–0.92)*a 86 (26)*b 74 (22)*c 17 (5)

An asterisk (*) in the ‘Overall’ row represents that there was an overall statistical difference between META and NO META TxGroups (a, Wilcoxon Sum Rank test, p = 0.002; b, χ2 test, p = 0.002; c, χ2 test, p = 0.0007). Values with different superscripts in the same column of the ‘META’ or ‘NO META’ rows represent a statistical difference between TxGroups within Trial (d-i, Wilcoxon Sum Rank, p ≤ 0.05; mn, op, and qr, χ2 test, p ≤ 0.05). Values with different superscripts in the same column of the ‘All’ rows represent a statistically significant difference among Trials (j-l, Kruskal Wallis Analysis of Variance on Ranks with post-hoc Dunn Test and Benjamini Hochberg Correction, p ≤ 0.05). #There was a significant difference between animals treated with antimicrobials and animals treated for BRD (McNemar’s χ2 Test, p = 0.001). Percentages represent percent of animals. TxGroup, treatment group; MH, Mannheimia haemolytica; MDR, multi-drug resistant; CI, confidence interval; ADG, average daily gain; BRD, bovine respiratory disease; META, tulathromycin metaphylaxis; NO META, no tulathromycin metaphylaxis.