Table 2. Plasma lipid profiles in mice fed on chow diet or Paigen’s diet.
| Each group (n = 5–9) | Chow diet | Atherogenic Paigen's diet | |||||
|---|---|---|---|---|---|---|---|
| Wild type mice | Wild type mice | ApoE-knockout mice | |||||
| 10 mg/kg PPE | 20 mg/kg PPE | 10 mg/kg α-asarone | 20 mg/kg α-asarone | ||||
| TC | 115.97 ± 3.41e | 192.01 ± 7.53d | 1,871.50 ± 154.49a | 1,336.61 ± 84.08c | 1,270.61 ± 62.22c | 1,514.16 ± 90.40b | 1,572.38 ± 87.46b |
| TG | 39.94 ± 2.11d | 47.97 ± 4.34c | 93.13 ± 4.58a | 86.83 ± 11.22a,b | 76.40 ± 9.542b | 73.078 ± 4.018b | 71.12 ± 6.32b |
| HDL-C | 58.45 ± 6.17a | 48.98 ± 5.41a | 6.13 ± 0.82c | 6.05 ± 1.31c | 8.88 ± 2.78b,c | 7.822 ± 1.148c | 11.48 ± 2.11b |
| LDL-C | 49.53 ± 6.30e | 133.43 ± 8.69d | 1,846.74 ± 154.20a | 1,313.19 ± 85.43c | 1,246.64 ± 59.63c | 1,491.72 ± 90.70b | 1,546.68 ± 87.45b |
| VLDL | 7.99 ± 0.42d | 9.59 ± 0.87c | 18.63 ± 0.92a | 17.37 ± 2.24a,b | 15.28 ± 1.91b | 14.62 ± 0.80b | 14.23 ± 1.26b |
| AI | 1.19 ± 0.23e | 3.46 ± 0.60d | 351.65 ± 53.58a | 288.82 ± 46.62a,b | 235.90 ± 83.81b | 231.48 ± 38.88b | 191.53 ± 32.16c |
Wild type mice and apoE-deficient mice were fed with chow diet or atherogenic Paigen’s diet for 10 wk with and without 10–20 mg/kg PPE or α-asarone. Wild type mice were fed chow diet as control mice. Blood lipid contents were analyzed by using commercial detection kits. LDL-C = TC − HDL-C − (TG/5). VLDL = TG/5. AI = (TC − HDL-C)/HDL-C. Statistical significance was determined with Duncan range test for multiple comparisons after 1-way analysis of variance. Respective values (mean ± SEM) not sharing a small alphabetical letter in the same row are different at P < 0.05.
apoE, apolipoprotein E; TC, total cholesterol; TG, triglyceride, HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; VLDL, very low-density lipoprotein; AI, atherosclerosis index; PPE, purple perilla frutescens extract.