Table 2.
Immunohistochemical expression of HIF-1α and VEGF-A in RCC according to clinicopathological characteristics of patients.
| HIF-1α score | P | VEGF-A score | P | |
|---|---|---|---|---|
| Sex | ||||
| Male (n=26) Female (n=13) |
18.18 ± 13.48 23.87 ± 14.21 |
0.2279* | 1.89 ± 1.23 3.02 ± 1.19 |
0.0115* |
| Type of surgery | ||||
| Radical nephrectomy (n=27) Partial nephrectomy (n=2) Tumorectomy (n=7) |
20.40 ± 14.85 28.43 ± 18.21 20.33 ± 10.39 |
0.6680† | 2.28 ± 1.32 2.10 ± 2.69 2.26 ± 1.17 |
0.9889† |
| Macroscopic tumor extension | ||||
| Confined to kidney (n=28) Extends beyond kidney (n=8) |
22.09 ± 14.00 16.41 ± 13.84 |
0.3943* | 2.32 ± 1.30 2.06 ± 1.44 |
0.6737* |
| Microscopic tumor extension | ||||
| Confined to kidney (n=26) Extends beyond kidney (n=10) |
23.29 ± 13.80 14.42 ± 12.92 |
0.1327* | 2.42 ± 1.29 1.84 ± 1.37 |
0.2885* |
| Clinical stage | ||||
| Stage I (n=25) Stage II (n=3) Stage III (n=8) |
22.73 ± 13.12 16.78 ± 23.05 16.41 ± 13.84 |
0.5465† | 2.38 ± 1.25 1.82 ± 1.93 2.06 ± 1.44 |
0.7471† |
| Histological subtype | ||||
| ccRCC (n=14) pRCC (n=13) chRCC (n=12) |
14.72 ± 12.07 28.52 ± 14.78 17.16 ± 10.88 |
0.0224† | 1.78 ± 1.21 2.61 ± 1.31 2.45 ± 1.38 |
0.2744† |
| Nuclear grade (Furham) | ||||
| low (n=16) high (n=18) |
17.74 ± 16.14 19.52 ± 11.93 |
0.5449* | 1.98 ± 1.32 2.53 ± 1.31 |
0.2000* |
| Tumor necrosis | ||||
| present (n=12) not present (n=24) |
23.29 ± 16.24 18.65 ± 12.66 |
0.2420* | 2.11 ± 1.34 2.33 ± 1.32 |
0.6899* |
*Mann-Whitney U test, †Kruskal-Wallis test with Uncorrected Dunn’s post-hoc test.