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. 2023 Sep 23;7(22):7045–7055. doi: 10.1182/bloodadvances.2023010841

Table 4.

Responsiveness to change (T1 compared with T2) of the scales and single items of the EORTC QLQ-HL27 (n = 98)

EORTC QLQ-HL27 T1
On treatment
T2
≥3 months after treatment
t statistic P value Difference between means Cohen d ES
n = 98
n = 98
Mean (SD) Mean (SD)
Scales
 Symptom burden 25.3 (21.2) 20.1 (19.0) 2.46 .02 5.2 0.26
 Physical condition/fatigue 35.1 (25.6) 25.3 (23.8) 3.80 <.01 9.8 0.40
 Emotional impact 28.0 (23.5) 24.7 (22.0) 1.24 .22 −3.3 0.15
 Worries/fears about health and functioning 42.0 (27.4) 42.3 (27.6) 0.54 .59 0.3 0.01
Single items (conditional)
 Problems at work/place of study 21.1 (34.2) 18.3 (32.3) 1.03 .30 −2.8 0.08
 Worries about work/study 28.3 (34.9) 24.6 (35.1) 0.88 .38 −3.7 0.10
 Concern about ability to have children 28.9 (36.7) 27.4 (37.0) 0.10 .92 −1.5 0.04

An ES of 0.2 is considered small; 0.5, moderate; and 0.8, large.42