Figure 5.

scCURE identified predictive R-like and NR-like macrophage cells from pre-treatment patients with melanoma

(A) The AUC and p values of prediction models obtained based on different choices of scCURE parameters.

(B) t-SNE plot of the scCURE-processed macrophage cells colored by cell type, cell group, and ICB response.

(C) Heatmap of M1 and M2 macrophage cell markers.

(D) The association between clusters and response patterns by hypergeometric test.

(E) The ratio of R-like and NR-like can well discriminate Rs and NRs.

(F) Circos plot depicting the performance of signatures of each cluster in three bulk melanoma cohorts. The vertical axis indicates AUC values.

(G) Enriched GSEA hallmarks of three predictive macrophage clusters (Benjamini-Hochberg [BH]-adjusted p < 0.05).