Figure 7.

scCURE identified predictive R-like and NR-like CD8⁺ T cells from pre-treatment patients with TNBC

(A) The AUC and p values of prediction models obtained using different choices of scCURE parameters.

(B) t-SNE plot of the scCURE-processed CD8⁺ T cells colored by cell type, cell group, and ICB response.

(C) Chord diagram showing the enrichment result between cell type and cell group by hypergeometric distribution.

(D) Heatmap of canonical CD8⁺ T cell functional markers.

(E) Histogram showing the well distribution of R-like/NR-like ratios between Rs and NRs.

(F) The multiple ROC plot depicting the predictive performance of the average expression of top 10 markers of each cluster in I-SPY2 cohort.

(G) Hallmark pathways enriched in the predictive macrophage clusters. Hypergeometric test. BH-adjusted p < 0.05.