(A) Variation in protein S activity according to the whole cohort and factor V Leiden mutation. FVL, factor V Leiden; HMZ, homozygous; HTZ, heterozygous. ∗: P value < .001. (B) Protein S activity value according to sex and age. M+ = Male aged >18 years with a positive FVL status, M− = male aged >18 years with a negative FVL status, W 18-50 + = women aged between 18 and 50 years with a positive FVL status, W 18-50 − = women aged between 18 and 50 years with a negative FVL status. W >50 + = women aged >50 years with a positive FVL status, W >50 − = women aged >50 years with a negative FVL status. ∗: P value < .001. N represents the sample size.