REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
anti-RAD51 (clone H-92)	Santa Cruz Biotechnology	Cat# sc-8349; RRID: AB_2253533
anti-γH2AX (clone 20E3)	Cell Signaling Technology	Cat# 9718; RRID: AB_2118009
anti-geminin (clone 1A8)	Abcam	Cat# ab104306; RRID: AB_10889692
anti-α tubulin	GeneTex	Cat# GTX112141; RRID: AB_10722892
anti-p53	GeneTex	Cat# GTX102965; RRID: AB_1952339
anti-GAPDH	GeneTex	Cat# GTX100118; RRID: AB_1080976
anti-pan cytokeratin (clone AE1/AE3)-Alexa Fluor 488 conjugated	Invitrogen	Cat# 53-9003-82; RRID: AB_1834350
anti-PAX8	Proteintech	Cat# 10336-1-AP; RRID: AB_2236705
Goat anti-rabbit IgG (HRP)	GeneTex	Cat# GTX213110–01; RRID: AB_10618573
Goat anti-rabbit IgG-DyLight 488 conjugated	Thermo Fisher Scientific	Cat# 35553; RRID: AB_1965947
Goat anti-mouse IgG-Alexa Fluor 647 conjugated	Thermo Fisher Scientific	Cat# A-21236; RRID: AB_2535805
Bacterial and virus strains
AdenoX-pCMV-I-SceI-mCherry	This paper	N/A
AdenoX-pCMV-DR-GFP-pPGK-ECFP	This paper	N/A
Biological samples
Primary ovarian cancer cells derived from tumor tissue	This paper	N/A
Primary ovarian cancer cells derived from ascites	This paper	N/A
Chemicals, peptides, and recombinant proteins
Olaparib	Selleckchem	Cat# S1060
B02	Cayman Chemical	Cat# 22133
Critical commercial assays
Adeno-X Adenoviral System 3	Clontech	Cat# 6322666
Adeno-X Maxi Purification Kit	Clontech	Cat# 631533
alamarBlue Cell Viability Reagent	Thermo Fisher Scientific	Cat# DAL1025
Tumor Dissociation Kit	Miltenyi Biotech	Cat# 130-095-929
Ammonium Chloride Solution	STEMCELL Technologies	Cat# 07850
Tumor Cell Isolation kit	Miltenyi Biotech	Cat# 130-108-339
QIAamp DNA Mini kit	QIAGEN	Cat# 51304
Deposited data
whole-exome sequencing datasets for OCC-2	This paper	https://www.ncbi.nlm.nih.gov/sra/SRX18246139
whole-exome sequencing datasets for OCC-3	This paper	https://www.ncbi.nlm.nih.gov/sra/SRX16742482
whole-exome sequencing datasets for OCC-5-a	This paper	https://www.ncbi.nlm.nih.gov/sra/SRX16742483
whole-exome sequencing datasets for OCC-7-a	This paper	https://www.ncbi.nlm.nih.gov/sra/SRX16742484
whole-exome sequencing datasets for OCC-9-a	This paper	https://www.ncbi.nlm.nih.gov/sra/SRX16742485
whole-exome sequencing datasets for OCC-10-a	This paper	https://www.ncbi.nlm.nih.gov/sra/SRX16742477
whole-exome sequencing datasets for OCC-12	This paper	https://www.ncbi.nlm.nih.gov/sra/SRX16742478
whole-exome sequencing datasets for OCC-14-a	This paper	https://www.ncbi.nlm.nih.gov/sra/SRX16742479
whole-exome sequencing dataset for OCC-28	This paper	https://www.ncbi.nlm.nih.gov/sra/SRX17907740
Experimental models: Cell lines
HeLa cells	ATCC	Cat# CCL-2; RRID: CVCL_0030
U2OS cells	ATCC	Cat# HTB-96
Hs578T cells	ATCC	Cat# HTB-126
MDA-MB-23 cells	ATCC	Cat# CRM-HTB-26
MDA-MB-436 cells	ATCC	Cat# HTB-130
SKOV3 cells	ATCC	Cat# HTB-77
TOV-21G cells	ATCC	Cat# CRL-3577
UWB1.289 cells	ATCC	Cat# CRL-2945
OVCA429 cells	Obtained from Ruby Yun-Ju Huang (National Taiwan University, Taiwan)	N/A
RMG1 cells	Obtained from Wendy W. Hwang-Verslues (Academia Sinica, Taiwan)	N/A
HCT116 cells	ECACC	Cat# 91091005
HCT116 BRCA2−/− cells	ECACC	Cat# 16071901
AdenoX-293 cells	Clontech	Cat# 632271
Oligonucleotides
siRNAs targeting human RAD51	GE Dharmacon	Cat# J-003530-10-0020
siRNA non-targeting pool control	GE Dharmacon	Cat# D-001810-10-20
Recombinant DNA
pCMV6-AC-GFP	OriGene	Cat# PS100010
pAdenoX-PRLS	Clontech	Cat# 632260
pAdenoX-pCMV-GFP	This paper	N/A
pAdenoX-pCMV-I-SceI-mCherry	This paper	N/A
pAdenoX-pCMV-DR-GFP-pPGK-ECFP	This paper	N/A
Software and algorithms
Burrows-Wheeler Aligner v0.5.9	https://bio-bwa.sourceforge.net/	https://bio-bwa.sourceforge.net/
SAM tools v0.1.18	https://samtools.sourceforge.net/	https://samtools.sourceforge.net/
Picard v1.54	https://github.com/broadinstitute/picard	https://github.com/broadinstitute/picard
Genome Analysis Toolkit v4	https://gatk.broadinstitute.org/hc/en-us	https://gatk.broadinstitute.org/hc/en-us
GraphPad Prism v7	https://www.graphpad.com/	https://www.graphpad.com/