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. 2023 Oct 20;4(11):101248. doi: 10.1016/j.xcrm.2023.101248

Figure 1.

Figure 1

Matrix ultrastructural analysis of PDAC desmoplasia

(A) CONSORT diagram of imaging and ultrastructural analysis for patients with PDAC.

(B) Ultrastructural quantification from histological images, including pseudotime modeling of ultrastructural states and integration with CODEX.

(C) Manifold of PDAC desmoplastic architecture with higher pseudotime representing increasingly disrupted, heterogeneous desmoplastic architecture. Boxed images show representative tiles along the pseudotime trajectory. Scale bars represent 100 μm.

(D) Visualization of healthy pancreas samples, which localize near the root point of the pseudotime trajectory.

(E and F) Integration of overall survival (E) and disease-free survival (F) with clinical metadata.

(G–I) Correlation of overall survival with patient-level pseudotime (G), stained quantity of fibrosis (H), and ultrastructural variance (I). Pearson coefficients and associated p values are shown.

(J–L) Correlation of disease-free survival with patient-level pseudotime (J), stained quantity of fibrosis (K), and ultrastructural variance (L). Pearson coefficients and associated p values are shown.