Figure 6.

Interactomes of cancer-associated fibroblasts and B lymphocytes, as well as their variation with protein phenotype

(A) Principal-component analysis (PCA) of fibroblast interaction space up to 5 PCs, as determined by vertex of scree plot. Fibroblasts appear to exhibit distinct interaction patterns that are defined by differences in inflammatory vs. mechanically activated protein expression.

(B) Heatmaps of PCA coefficients and centroids for each fibroblast subtype.

(C) PCA of B lymphocyte interaction space up to 4 principal components, as determined by vertex of scree plot. B lymphocytes appear to exhibit distinct interaction patterns based on maturity of protein phenotype.

(D) Heatmaps of PCA coefficients and centroids for each B lymphocyte subtype.