Table 2.
Diagnostic performance of C-DAG algorithm for identifying patients with NASH
| Training set (n = 326) | Test set (n = 163) | External validation cohort (n = 135) | Pooled validation cohort (n = 298) | |
|---|---|---|---|---|
| Number of patients with NASH | 125 | 66 | 43 | 109 |
| AUROC (95% CI) | 0.911 (0.881–0.941) | 0.891 (0.844–0.939) | 0.895 (0.844–0.946) | 0.893 (0.859–0.927) |
| Delong’s test p (vs. sCDCP1) | <0.001 | 0.071 | 0.017 | 0.004 |
| Rule-out cutoff | <0.235 | <0.235 | <0.235 | <0.235 |
| n (%) | 166 (50.9) | 69 (42.3) | 77 (57.0) | 145 (48.7) |
| Sensitivity, % | 90.3 | 93.9 | 86.0 | 90.8 |
| Specificity, % | 76.1 | 66.0 | 77.2 | 71.4 |
| NPV, % | 92.7 | 94.1 | 92.2 | 93.1 |
| Rule-in cutoff | ≥0.393 | ≥0.393 | ≥0.393 | ≥0.393 |
| n (%) | 111 (34.0) | 73 (44.8) | 42 (31.1) | 115 (38.6) |
| Sensitivity, % | 72.8 | 77.3 | 65.1 | 72.5 |
| Specificity, % | 90.0 | 78.4 | 85.9 | 81.5 |
| PPV, % | 82.0 | 70.8 | 68.3 | 69.3 |
| Gray zone n (%) | 49 (15.0) | 21 (12.9) | 16 (11.9) | 38 (12.8) |
The pooled validation cohort combines the test sets of the main cohort and the external validation cohort. NASH, non-alcoholic steatohepatitis; PPV, positive predictive value; NPV, negative predictive value.