Figure 4.
CAM003 IgA1mRNA and IgG1mRNA protect mice against lethal challenge in a P. aeruginosa acute pneumonia model
Adult BALB/c mice were injected intravenously with 1 mg/kg formulated mRNA encoding CAM003 as an IgG1 or an IgA1 and were intranasally challenged 24 h later with 6.75 log10 CFU P. aeruginosa strain PA01. Mice were monitored for survival for 6 days following challenge.
(A) Circulating antibody concentration in serum prior to challenge by isotype-specific ELISA (n = 10/group). Each symbol represents an individual mouse, and data is graphed mean ± SD, ∗∗∗∗p < 0.0001
(B) Kaplan-Meier survival curves.