Figure 4.

Public clonotype analysis of SARS-CoV-2 antibodies from children

(A) For each antibody from children (separate plot), shown are previously published adult antibodies (dots), with the respective CDRH3 (x axis) and CDRL3 (y axis) identity, colored according to V-gene usage: blue if both the VH and VL genes of the given child and adult antibodies match, orange if only the VH genes match, purple if only the VL genes match, and gray if neither match but at least one of the CDRH3 and CDRL3 have >50% sequence identity for the child vs. adult antibody.

(B) For each antibody from children (column), shown is the CDRH3 identity (values; heatmap) against a set of adult antibodies in clinical use or advanced preclinical development (rows). Cell border color corresponds to the V-gene usage described in (A).