Figure 1.

Cell-free multi-omics data summary and quality control

(A) Cell-free multi-omics data in plasma. Numbers inside and outside of brackets are datasets and samples, respectively, where some samples were mixed for sequencing. The gap in the ring means no paired data.

(B) Multi-omics reads mapped on a housekeeping gene, GAPDH, and a tumor suppressor gene, TP53. The coverage is normalized by total mapped reads. Red dashed line, the average coverage of cfDNA reads mapped on a gene.

(C) Density plots of multi-omics correlation coefficients of genes in tissues (TCGA), cell lines (CCLE), and plasma (this study).