Fig. 3.

ARB modulates energy metabolism and oxidative stress in mice to ameliorate ferroptosis. (A–B) O₂ consumed (n = 3–4 per group). (C–D) CO₂ produced (n = 3–4 per group). (E–F) RER (VO₂/VCO₂) (n = 3–4 per group). (G–H) Energy metabolism (n = 3–4 per group). (I–K) Effect of 1 g/kg ARB on liver ROS, GSH, and MDA in mice (n = 6 per group). (L–N) Fe, Fe²⁺, and Fe²⁺ to Fe³⁺ ratio (n = 6 per group). (O) Serum Fe (n = 6 per group). (P) qPT-PCR of ferroptosis-related genes (n = 4–5 per group). (Q–R) Changes in SLC7A11 protein levels in mice liver of 1 g/kg ARB treatment (n = 6 per group). Data are mean ± SEM, n ≥ 3; ∗P < 0.05; ∗∗P < 0.01. (K–R) Data are mean ± SEM, n ≥ 6; One-way ANOVA was used to compare the means of three groups, ∗P < 0.05; ∗∗P < 0.01.