Fig. 7.

AAV-mediated SLC7A11 hepatic overexpression alleviates fatty liver in mice. (A) Schematic diagram of the experimental process in mice. (B) Pictures of mice body size. (C–E) NMR test the body weight and body fat percentage of mice (n = 6–7 per group). (F) CT pictures of mice. (G–I) Pictures of epididymal and subcutaneous fat and relative weights. (J–K) Pictures of liver and relative weights. (L) H&E staining of epididymal fat. (M) H&E staining of liver and oil red O staining. (N–O) Liver TG and TC content in different groups of mice. (P–Q) Serum TG, TC levels in different groups of mice (n = 6–7 per group). (R–S) Mice treated at week 6 for GTT assay (n = 5–6 per group). (T–U) ITT assay at week 7 of mice treatment (n = 6 per group). Data are mean ± SEM, n ≥ 6; One-way ANOVA was used to compare the means of four groups, ∗P < 0.05; ∗∗P < 0.01. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)