Fig. 8.

AAV-mediated SLC7A11 hepatic overexpression improves energy metabolism and reduces oxidative stress. (A–B) O₂ consumed (n = 5 per group). (C–D) CO₂ produced (n = 5 per group). (E–F) RER (VO₂/VCO₂) (n = 5 per group). (G–H) Energy metabolism (n = 5 per group). (I–K) Effect of SLC7A11 infection of the liver on ROS, GSH, and MDA (n = 6–7 per group). (L–N) Fe, Fe²⁺, and Fe²⁺ to Fe³⁺ ratio (n = 6–7 per group). (O) Serum Fe levels (n = 6–7 per group). Data are mean ± SEM, n ≥ 5; One-way ANOVA was used to compare the means of four groups, ∗P < 0.05; ∗∗P < 0.01.