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. 2023 Dec 4;13(50):35216–35230. doi: 10.1039/d3ra06333j

Acylation of rutin with 20 g dm−3CalB immobilized on Immobead 150 under a variety of conditions.

Exp. no. Solvent Conditions Dehydrating agent Fatty acid Conversion ratio
1 10 : 1 acetone : DMSO 50 °C, 96 h MS4Å (100 g dm−3) Octanoic acid (100 eq.) 21%
2 10 : 1 acetone : DMSO 50 °C, 96 h MS4Å (100 g dm−3) Octanoic acid (10 eq.) Nil
3 10 : 1 acetone : DMSO 50 °C, 96 h MS4Å (100 g dm−3) Octanoic acid (4 eq.) Nil
4 10 : 1 acetone : DMSO 50 °C, 96 h MS4Å (50 g dm−3) Octanoic acid (100 eq.) 32%
5 10 : 1 acetone : DMSO 50 °C, 96 h MS4Å (100 g dm−3) Butyric acid (100 eq.) 24%
6 10 : 1 acetone : DMSO 50 °C, 96 h MS4Å (100 g dm−3) 2-Methylbutyric acid (100 eq.) Nil
7 Isopropanol 50 °C, 96 h MS4Å (100 g dm−3) Octanoic acid (100 eq.) Nil
8 10 : 1 2-butanone : DMSO 50 °C, 96 h MS4Å (100 g dm−3) Octanoic acid (100 eq.) Nil
9 Acetonitrile 55 °C, 48 h MS4Å (100 g dm−3) Octanoic acid (100 eq.) 34%
10 10 : 1 acetonitrile : DMSO 55 °C, 96 h MS4Å (100 g dm−3) Octanoic acid (100 eq.) 45%
11 10 : 1 acetonitrile : DMSO 55 °C, 96 h MS4Å (100 g dm−3) Octanoic acid (10 eq.) 34%
12 10 : 1 acetonitrile : DMSO 55 °C, 96 h None Octanoic acid (10 eq.) 20%
13 10 : 1 acetonitrile : DMSO 55 °C, 48 h SiO2 (32.9 g dm−3) Octanoic acid (100 eq.) 47%
14 10 : 1 acetonitrile : DMSO 55 °C, 96 h MS4Å (100 g dm−3) 2-Methylbutyric acid (100 eq.) Traces
15 10 : 1 acetonitrile : DMSO 55 °C, 96 h MS4Å (100 g dm−3) Palmitic acid (50 eq.) Traces
16 10 : 1 acetonitrile : DMSO 55 °C, 96 h MS4Å (100 g dm−3) p-Coumaric acid (50 eq.) Nil