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. 2023 Dec 4;13(50):35240–35250. doi: 10.1039/d3ra07035b

BBB assay of key benzyloxy chalcone compounds using the PAMPA methoda.

Compound Experimental Pe (×10−6 cm s−1) Prediction
ISB1 4.93 ± 0.13 CNS+
ISFB1 4.09 ± 0.24 CNS+
Selegiline 5.69 ± 0.04 CNS+
a

Pe (10−6 cm s−1) > 4.00: CNS+ (high permeation).