Table 4.
Effect size of MCC950 on IL-1β secretion from peripheral blood mononuclear cells
| Non-severe vs Healthy | Severe vs Healthy | Severe vs Non-severe | Severe vs Severe (exacerbating) | |
|---|---|---|---|---|
|
Media (2 h) |
||||
| Mean diff. (95% CI) |
− 0.3 (− 1.1 to 0.5) |
0.3 (− 1.0 to 1.6) |
0.5 (− 0.7 to 1.8) |
0.1 (− 1.5 to 1.7) |
| P value | 0.5016 | 0.6882 | 0.3812 | 0.9070 |
|
LPS (2 h) |
||||
| Mean diff. (95% CI) |
− 13.5 (− 40.2 to 13.3) |
− 28.2 (− 59.2 to 2.8) |
− 14.7 (− 51.8 to 22.3) |
− 68.8 (− 178.6 to 41.0) |
| P value | 0.3244 | 0.0755 | 0.4355 | 0.2202 |
| Nigericin (1 h) | ||||
| Mean diff. (95% CI) |
− 32.2 (− 120.9 to 56.5) |
− 113.9 (− 213.6 to − 14.2) |
− 81.7 (− 162.7 to − 0.8) |
− 76.0 (− 251.7 to 99.7) |
| P value | 0.4773 | 0.0256 | 0.0484 | 0.3970 |
| LPS (2 h) + Nigericin (1 h) | ||||
| Mean diff. (95% CI) |
240.2 (− 412.3 to 892.7) |
− 1380.9 (− 2399.2 to − 362.5) |
− 1621.0 (− 2589.7 to − 652.4) |
− 937.6 (− 2363.3 to 488.1) |
| P value | 0.4710 | 0.0082 | 0.0011 | 0.1981 |
|
Media (4 h) |
||||
| Mean diff. (95% CI) |
− 2.4 (− 11.6 to 6.8) |
2.2 (− 0.9 to 5.4) |
4.6 (− 4.0 to 13.3) |
1.5 (− 0.4 to 3.5) |
| P value | 0.6096 | 0.1600 | 0.2948 | 0.1293 |
|
LPS (4 h) |
||||
| Mean diff. (95% CI) |
− 30.3 (− 74.4 to 13.8) |
− 66.8 (− 128.9 to − 4.7) |
− 36.5 (− 99.4 to 26.4) |
29.5 (− 87.9 to 146.8) |
| P value | 0.1783 | 0.0357 | 0.2560 | 0.6229 |
|
Nigericin (1 h) |
||||
| Mean diff. (95% CI) |
− 73.6 (− 118.2 to − 29.1) |
− 99.7 (− 143.4 to − 56.1) |
− 26.1 (− 86.0 to 33.8) |
62.0 (− 109.8 to 233.8) |
| P value | 0.0013 | < 0.0001 | 0.3933 | 0.4799 |
| LPS (4 h) + Nigericin (1 h) | ||||
| Mean diff. (95% CI) |
− 79.3 (− 1646.5 to 1487.9) |
− 3735.3 (− 6046.7 to − 1423.8) |
− 3655.9 (− 5915.2 to − 1396.7) |
103.4 (38.1 to 168.8) |
| P value | 0.9210 | 0.0016 | 0.0016 | 0.0020 |
LPS Lipopolysaccharide
Descriptive statistics are shown as mean difference (95% confidence interval)